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Beilstein J. Org. Chem. 2021, 17, 2321–2328, doi:10.3762/bjoc.17.150
Graphical Abstract
Figure 1: Representation of bioactive molecules and applications.
Scheme 1: Synthetic methodologies for 3-monohalooxindoles.
Scheme 2: Substrate scope of the acidolysis of isatin-derived phosphates 2 with hydrochloric acid. Standard r...
Scheme 3: Substrate scope of the acidolysis of isatin-derived phosphates 2 with hydrobromic acid. Standard re...
Scheme 4: Reduction of the substrates 2 to the corresponding oxindoles 5.
Scheme 5: Plausible reaction mechanism.